| Round | Pick | Team | Position | First | Last | Player ID |
|---|
| ROUND 1 |
| 1 | 1 | Cleveland | CB | Kyle | Wilson | |
| 1 | 2 | Denver | HB | C.J. | Spiller | |
| 1 | 3 | Indianapolis | WR | Golden | Tate | |
| 1 | 4 | Philadelphia | CB | Kareem | Jackson | |
| 1 | 5 | Cleveland | LB | Rolando | McClain | |
| 1 | 6 | Pittsburgh | CB | Joe | Haden | |
| 1 | 7 | Green Bay | FB | Clay | Harbor | |
| 1 | 8 | Dallas | T | Bryan | Bulaga | |
| 1 | 9 | Seattle | WR | Emmanuel | Sanders | |
| 1 | 10 | New England | WR | Dexter | McCluster | |
| 1 | 11 | Oakland | DT | Gerald | McCoy | |
| 1 | 12 | Buffalo | DE | Derrick | Morgan | |
| 1 | 13 | Tampa Bay | DE | Everson | Griffen | |
| 1 | 14 | New York N | CB | Chris | Cook | |
| 1 | 15 | Atlanta | DE | Jerry | Hughes | |
| 1 | 16 | Buffalo | LB | Sergio | Kindle | |
| 1 | 17 | San Francisco | S | Eric | Berry | |
| 1 | 18 | San Diego | WR | Brandon | LaFell | |
| ROUND 2 |
| 2 | 1 | Cleveland | G | Zane | Beadles | |
| 2 | 2 | Denver | DE | Jermaine | Cunningham | |
| 2 | 3 | Indianapolis | HB | Toby | Gerhart | |
| 2 | 4 | Philadelphia | QB | Jimmy | Clausen | |
| 2 | 5 | Atlanta | LB | Daryl | Washington | |
| 2 | 6 | Pittsburgh | G | Jon | Asamoah | |
| 2 | 7 | Green Bay | WR | Eric | Decker | |
| 2 | 8 | Dallas | T | Austin | Howard | |
| 2 | 9 | Seattle | LB | Eric | Norwood | |
| 2 | 10 | New England | G | Marshall | Newhouse | |
| 2 | 11 | Oakland | HB | Ben | Tate | |
| 2 | 12 | Buffalo | DT | Dan | Williams | |
| 2 | 13 | Tampa Bay | LB | Matt | Mayberry | |
| 2 | 14 | New York N | T | Vladimir | Ducasse | |
| 2 | 15 | Atlanta | DT | Linval | Joseph | |
| 2 | 16 | New York A | T | Anthony | Davis | |
| 2 | 17 | San Francisco | CB | Jerome | Murphy | |
| 2 | 18 | San Diego | T | Jason | Fox | |
| ROUND 3 |
| 3 | 1 | Cleveland | T | Bruce | Campbell | |
| 3 | 2 | Denver | CB | Akwasi | Owusu-Ansah | |
| 3 | 3 | Indianapolis | DT | Jared | Odrick | |
| 3 | 4 | Philadelphia | HB | Jonathan | Dwyer | |
| 3 | 5 | Atlanta | HB | Joe | McKnight | |
| 3 | 6 | Buffalo | S | Nate | Allen | |
| 3 | 7 | Detroit | CB | Perrish | Cox | |
| 3 | 8 | Dallas | LB | Jeremy | Maddox | |
| 3 | 9 | Seattle | S | Reshad | Jones | |
| 3 | 10 | New England | C | Maurkice | Pouncey | |
| 3 | 11 | Oakland | LB | Donald | Butler | |
| 3 | 12 | Buffalo | CB | Patrick | Robinson | |
| 3 | 13 | Tampa Bay | WR | Taylor | Price | |
| 3 | 14 | New York N | TE | Jermaine | Gresham | |
| 3 | 15 | Atlanta | T | Sam | Young | |
| 3 | 16 | Buffalo | WR | Marc | Mariani | |
| 3 | 17 | San Francisco | TE | Jimmy | Graham | |
| 3 | 18 | Buffalo | S | T.J. | Ward | |
| ROUND 4 |
| 4 | 1 | Cleveland | G | Shawn | Lauvao | |
| 4 | 2 | Denver | WR | Jacoby | Ford | |
| 4 | 3 | Indianapolis | DE | Daniel | Te'o-Nesheim | |
| 4 | 4 | Dallas | CB | Walter | Thurmond | |
| 4 | 5 | Cleveland | CB | Walter | McFadden | |
| 4 | 6 | Pittsburgh | S | Larry | Asante | |
| 4 | 7 | Detroit | LB | Sean | Lee | |
| 4 | 8 | Dallas | CB | Kevin | Thomas | |
| 4 | 9 | Seattle | G | Mike | Johnson | |
| 4 | 10 | New England | WR | David | Gettis | |
| 4 | 11 | Oakland | T | J'Marcus | Webb | |
| 4 | 12 | Buffalo | TE | Ed | Dickson | |
| 4 | 13 | Tampa Bay | HB | LeGarrette | Blount | |
| 4 | 14 | New York N | LB | Austin | Spitler | |
| 4 | 15 | Cleveland | C | JD | Walton | |
| 4 | 16 | New York A | HB | Charles | Scott | |
| 4 | 17 | San Francisco | LB | Sam | Maxwell | |
| 4 | 18 | Buffalo | DE | Willie | Young | |
| ROUND 5 |
| 5 | 1 | Cleveland | QB | John | Skelton | |
| 5 | 2 | Denver | WR | Trindon | Holliday | |
| 5 | 3 | Indianapolis | DT | Geno | Atkins | |
| 5 | 4 | Philadelphia | QB | Tim | Tebow | |
| 5 | 5 | Tampa Bay | WR | Antonio | Brown | |
| 5 | 6 | Pittsburgh | DT | Arthur | Jones | |
| 5 | 7 | Detroit | LB | Dekoda | Watson | |
| 5 | 8 | Dallas | G | Chris | DeGeare | |
| 5 | 9 | Seattle | WR | Riley | Cooper | |
| 5 | 10 | New England | LB | A.J. | Edds | |
| 5 | 11 | Oakland | QB | Mike | Kafka | |
| 5 | 12 | New York A | CB | Nolan | Carroll | |
| 5 | 13 | Tampa Bay | DE | Clifton | Geathers | |
| 5 | 14 | New York N | G | Alex | Parsons | |
| 5 | 15 | San Diego | P | Zoltan | Mesko | |
| 5 | 16 | Green Bay | DT | Lamarr | Houston | |
| 5 | 17 | San Francisco | T | Kyle | Calloway | |
| 5 | 18 | San Diego | HB | Deji | Karim | |
| ROUND 6 |
| 6 | 1 | Cleveland | G | Brian | Simmons | |
| 6 | 2 | Denver | DT | Nate | Collins | |
| 6 | 3 | Indianapolis | K | Aaron | Pettrey | |
| 6 | 4 | Philadelphia | S | Major | Wright | |
| 6 | 5 | Atlanta | QB | Jevan | Snead | |
| 6 | 6 | Pittsburgh | CB | Alterraun | Verner | |
| 6 | 7 | Detroit | QB | Daryll | Clark | |
| 6 | 8 | Dallas | QB | Tim | Hiller | |
| 6 | 9 | Seattle | LB | Keenan | Clayton | |
| 6 | 10 | New England | C | AJ | Trump | |
| 6 | 11 | Oakland | FB | Rashawn | Jackson | |
| 6 | 12 | Dallas | HB | Carlos | Brown | |
| 6 | 13 | Atlanta | WR | Alric | Arnett | |
| 6 | 14 | New York N | LB | Rennie | Curran | |
| 6 | 15 | Detroit | LB | Roddrick | Muckelroy | |
| 6 | 16 | New York A | S | Kurt | Coleman | |
| 6 | 17 | San Francisco | WR | Seyi | Ajirotutu | |
| 6 | 18 | San Diego | DE | Erik | Lorig | |
| ROUND 7 |
| 7 | 1 | Cleveland | T | Chris | Marinelli | |
| 7 | 2 | Denver | QB | Dan | LeFevour | |
| 7 | 3 | Indianapolis | DT | Corey | Peters | |
| 7 | 4 | Philadelphia | WR | Mike | Williams | |
| 7 | 5 | Atlanta | S | Myron | Rolle | |
| 7 | 6 | Pittsburgh | WR | Jeremy | Williams | |
| 7 | 7 | Detroit | TE | Garrett | Graham | |
| 7 | 8 | Dallas | T | Ramon | Harewood | |
| 7 | 9 | Seattle | QB | Riley | Skinner | |
| 7 | 10 | New England | WR | Joe | Webb | |
| 7 | 11 | Oakland | QB | Levi | Brown | |
| 7 | 12 | San Diego | DE | Austen | Lane | |
| 7 | 13 | Tampa Bay | DT | Tyson | Alualu | |
| 7 | 14 | New York N | QB | Joey | Elliott | |
| 7 | 15 | Detroit | P | Matt | Dodge | |
| 7 | 16 | New York A | S | Shann | Schillinger | |
| 7 | 17 | San Francisco | T | Justin | Jeffries | |
| 7 | 18 | San Diego | T | Will | Barker | |