| Round | Pick | Team | Position | First | Last | Player ID |
|---|
| ROUND 1 |
| 1 | 1 | Pittsburgh | WR | Dez | Bryant | |
| 1 | 2 | Cleveland | S | Taylor | Mays | |
| 1 | 3 | Seattle | S | Chad | Jones | |
| 1 | 4 | Green Bay | CB | Devin | McCourty | |
| 1 | 5 | Indianapolis | LB | Brandon | Graham | |
| 1 | 6 | Oakland | HB | Ryan | Mathews | |
| 1 | 7 | Atlanta | LB | Sean | Weatherspoon | |
| 1 | 8 | Denver | CB | Earl | Thomas | |
| 1 | 9 | Philadelphia | T | Russell | Okung | |
| 1 | 10 | Jacksonville | DE | Carlos | Dunlap | |
| 1 | 11 | New England | DE | Jason | Pierre-Paul | |
| 1 | 12 | San Diego | LB | Brandon | Spikes | |
| 1 | 13 | San Francisco | CB | Amari | Spievey | |
| 1 | 14 | Green Bay | CB | Trevard | Lindley | |
| 1 | 15 | New York A | WR | Demaryius | Thomas | |
| 1 | 16 | New York N | CB | Dominique | Franks | |
| 1 | 17 | Tampa Bay | CB | Syd Quan | Thompson | |
| 1 | 18 | Buffalo | QB | Sam | Bradford | |
| ROUND 2 |
| 2 | 1 | Pittsburgh | DT | Ndamukong | Suh | |
| 2 | 2 | Jacksonville | LB | Pat | Angerer | |
| 2 | 3 | Seattle | DT | Brian | Price | |
| 2 | 4 | Jacksonville | HB | Jahvid | Best | |
| 2 | 5 | Indianapolis | LB | Jamar | Chaney | |
| 2 | 6 | Oakland | WR | Arrelious | Benn | |
| 2 | 7 | Atlanta | T | Trent | Williams | |
| 2 | 8 | Denver | DT | Terrence | Cody | |
| 2 | 9 | Philadelphia | CB | Javier | Arenas | |
| 2 | 10 | Buffalo | G | Mike | Iupati | |
| 2 | 11 | New England | LB | Jason | Worilds | |
| 2 | 12 | San Diego | T | Rodger | Saffold | |
| 2 | 13 | San Francisco | HB | Montario | Hardesty | |
| 2 | 14 | Jacksonville | CB | Rafael | Priest | |
| 2 | 15 | New York A | G | Brandon | Carter | |
| 2 | 16 | Buffalo | CB | AJ | Jefferson | |
| 2 | 17 | Tampa Bay | CB | Brandon | Ghee | |
| 2 | 18 | New York N | TE | Rob | Gronkowski | |
| ROUND 3 |
| 3 | 1 | Pittsburgh | LB | Perry | Riley | |
| 3 | 2 | Cleveland | WR | Jordan | Shipley | |
| 3 | 3 | Seattle | DE | Alex | Carrington | |
| 3 | 4 | Jacksonville | S | Morgan | Burnett | |
| 3 | 5 | Indianapolis | CB | Devin | Ross | |
| 3 | 6 | Oakland | LB | Phillip | Dillard | |
| 3 | 7 | Atlanta | T | Charles | Brown | |
| 3 | 8 | Denver | S | Kam | Chancellor | |
| 3 | 9 | Philadelphia | WR | Damian | Williams | |
| 3 | 10 | Cleveland | CB | Thad | Turner | |
| 3 | 11 | New England | CB | Jamar | Wall | |
| 3 | 12 | San Diego | DE | Corey | Wootton | |
| 3 | 13 | San Francisco | G | Ciron | Black | |
| 3 | 14 | Atlanta | CB | Sherrick | McMannis | |
| 3 | 15 | New York A | T | Jared | Veldheer | |
| 3 | 16 | Buffalo | HB | James | Starks | |
| 3 | 17 | Tampa Bay | S | Donovan | Warren | |
| 3 | 18 | Buffalo | DT | Torrell | Troup | |
| ROUND 4 |
| 4 | 1 | Pittsburgh | HB | Andre | Dixon | |
| 4 | 2 | Cleveland | QB | Colt | McCoy | |
| 4 | 3 | Seattle | DE | Brandon | Lang | |
| 4 | 4 | Jacksonville | FB | John | Conner | |
| 4 | 5 | Indianapolis | S | Darrell | Stuckey | |
| 4 | 6 | Oakland | TE | Tony | Moeaki | |
| 4 | 7 | Atlanta | G | Jacques | McClendon | |
| 4 | 8 | Denver | LB | Navorro | Bowman | |
| 4 | 9 | Detroit | CB | RJ | Stanford | |
| 4 | 10 | Cleveland | WR | Mardy | Gilyard | |
| 4 | 11 | New England | DT | Jeff | Owens | |
| 4 | 12 | San Diego | G | Shelley | Smith | |
| 4 | 13 | San Francisco | C | Matt | Tennant | |
| 4 | 14 | Oakland | FB | Jamie | McCoy | |
| 4 | 15 | New York A | TE | Aaron | Hernandez | |
| 4 | 16 | New York N | CB | Myron | Lewis | |
| 4 | 17 | Tampa Bay | HB | Brandon | West | |
| 4 | 18 | Detroit | HB | Anthony | Dixon | |
| ROUND 5 |
| 5 | 1 | Pittsburgh | DT | Earl | Mitchell | |
| 5 | 2 | Cleveland | HB | Joique | Bell | |
| 5 | 3 | Seattle | CB | Patrick | Stoudamire | |
| 5 | 4 | Green Bay | DE | Jan | Jorgensen | |
| 5 | 5 | Indianapolis | CB | Phillip | Adams | |
| 5 | 6 | Oakland | C | Ted | Larsen | |
| 5 | 7 | Atlanta | G | Mitch | Petrus | |
| 5 | 8 | Denver | P | Brent | Bowden | |
| 5 | 9 | Philadelphia | CB | Crezdon | Butler | |
| 5 | 10 | Green Bay | DE | Jammie | Kirlew | |
| 5 | 11 | New England | T | Ed | Wang | |
| 5 | 12 | San Diego | DE | George | Selvie | |
| 5 | 13 | San Francisco | T | Tyler | Eastman | |
| 5 | 14 | Jacksonville | HB | Daniel | Porter | |
| 5 | 15 | New York A | DE | C.J. | Wilson | |
| 5 | 16 | New York N | LB | Travis | Goethel | |
| 5 | 17 | Tampa Bay | HB | Toney | Baker | |
| 5 | 18 | Buffalo | QB | Jarrett | Brown | |
| ROUND 6 |
| 6 | 1 | Pittsburgh | TE | Jeff | Cumberland | |
| 6 | 2 | Cleveland | G | John | Jerry | |
| 6 | 3 | Seattle | DE | Hall | Davis | |
| 6 | 4 | Green Bay | S | Dominique | Harris | |
| 6 | 5 | Indianapolis | T | Thomas | Welch | |
| 6 | 6 | Oakland | S | Aaron | Webster | |
| 6 | 7 | Atlanta | DE | Mitch | Unrein | |
| 6 | 8 | Denver | T | Adam | Lambert | |
| 6 | 9 | Philadelphia | G | Mike | Tepper | |
| 6 | 10 | Green Bay | WR | Carlton | Mitchell | |
| 6 | 11 | New England | QB | Max | Hall | |
| 6 | 12 | San Diego | G | Ben | Ossai | |
| 6 | 13 | San Francisco | WR | Blair | White | |
| 6 | 14 | Jacksonville | LB | Nate | Triplett | |
| 6 | 15 | New York A | LB | Kavell | Conner | |
| 6 | 16 | New York N | LB | Rico | McCoy | |
| 6 | 17 | Tampa Bay | K | Leigh | Tiffin | |
| 6 | 18 | Detroit | WR | Armanti | Edwards | |
| ROUND 7 |
| 7 | 1 | Pittsburgh | FB | Nick | Tow-Arnett | |
| 7 | 2 | Cleveland | T | Nick | McDonald | |
| 7 | 3 | Seattle | DT | D'Anthony | Smith | |
| 7 | 4 | Green Bay | HB | Curtis | Steele | |
| 7 | 5 | Indianapolis | HB | Mikell | Simpson | |
| 7 | 6 | Oakland | WR | Marcus | Easley | |
| 7 | 7 | Atlanta | C | Joe | Hawley | |
| 7 | 8 | Denver | CB | Prince | Miler | |
| 7 | 9 | Philadelphia | TE | Dennis | Pitta | |
| 7 | 10 | Green Bay | DE | James | Ruffin | |
| 7 | 11 | New England | HB | Andre | Anderson | |
| 7 | 12 | San Diego | CB | Brandon | Brinkley | |
| 7 | 13 | San Francisco | LB | Blaze | Soares | |
| 7 | 14 | Jacksonville | T | Zipp | Duncan | |
| 7 | 15 | New York A | T | Adam | Ulatoski | |
| 7 | 16 | New York N | T | Selvish | Capers | |
| 7 | 17 | Tampa Bay | DT | Ekom | Udofia | |
| 7 | 18 | New York N | DT | Cam | Thomas | |