| Round | Pick | Team | Position | First | Last | Player ID |
|---|
| ROUND 1 |
| 1 | 1 | Dallas | DE | Dion | Gales | |
| 1 | 2 | Seattle | LB | Aaron | Curry | |
| 1 | 3 | Philadelphia | LB | Clay | Matthews | |
| 1 | 4 | Indianapolis | LB | Paul | Kruger | |
| 1 | 5 | San Diego | DE | Larry | English | |
| 1 | 6 | New York A | DE | Aaron | Maybin | |
| 1 | 7 | Oakland | CB | Danny | Gorrer | |
| 1 | 8 | Pittsburgh | WR | Darrius | Heyward-Bey | |
| 1 | 9 | New England | T | Andre | Smith | |
| 1 | 10 | San Francisco | HB | Donald | Brown | |
| 1 | 11 | Detroit | CB | Marquice | Cole | |
| 1 | 12 | San Diego | CB | Malcolm | Jenkins | |
| 1 | 13 | Detroit | QB | Mark | Sanchez | |
| 1 | 14 | Tampa Bay | LB | Rey | Maualuga | |
| 1 | 15 | Denver | T | Phil | Loadholt | |
| 1 | 16 | Green Bay | CB | Reggie | Jones | |
| 1 | 17 | New York N | CB | Louis | Delmas | |
| 1 | 18 | Buffalo | WR | Jeremy | Maclin | |
| ROUND 2 |
| 2 | 1 | Dallas | WR | Hakeem | Nicks | |
| 2 | 2 | Seattle | CB | Bruce | Johnson | |
| 2 | 3 | Philadelphia | DT | Peria | Jerry | |
| 2 | 4 | Indianapolis | S | Mike | Mitchell | |
| 2 | 5 | Detroit | T | Michael | Oher | |
| 2 | 6 | Buffalo | S | Michael | Mitchell | |
| 2 | 7 | Oakland | LB | Tyrone | McKenzie | |
| 2 | 8 | Pittsburgh | CB | Bradley | Fletcher | |
| 2 | 9 | New England | G | Michael | Unger | |
| 2 | 10 | San Francisco | CB | Darius | Butler | |
| 2 | 11 | Detroit | CB | D.J. | Johnson | |
| 2 | 12 | San Diego | LB | Slade | Norris | |
| 2 | 13 | Washington | CB | Darcel | McBath | |
| 2 | 14 | Tampa Bay | HB | Louis | Rankin | |
| 2 | 15 | Denver | WR | Mohamed | Massaquoi | |
| 2 | 16 | Green Bay | DT | Ron | Brace | |
| 2 | 17 | New York N | WR | Brian | Robiskie | |
| 2 | 18 | Buffalo | HB | LeSean | McCoy | |
| ROUND 3 |
| 3 | 1 | Dallas | TE | Matthew | Mulligan | |
| 3 | 2 | Seattle | QB | Stephen | McGee | |
| 3 | 3 | Philadelphia | S | Sherrod | Martin | |
| 3 | 4 | Indianapolis | CB | Lardarius | Webb | |
| 3 | 5 | Detroit | DE | Michael | Benett | |
| 3 | 6 | Detroit | LB | Jason | Williams | |
| 3 | 7 | Oakland | DT | Jarron | Gilbert | |
| 3 | 8 | Pittsburgh | QB | Nate | Davis | |
| 3 | 9 | New England | LB | Victor | Butler | |
| 3 | 10 | San Francisco | T | T.J. | Lang | |
| 3 | 11 | Detroit | S | David | Bruton | |
| 3 | 12 | San Diego | CB | Kevin | Barnes | |
| 3 | 13 | Washington | WR | Brandon | Tate | |
| 3 | 14 | Tampa Bay | G | Andy | Levitre | |
| 3 | 15 | Denver | DE | Everette | Brown | |
| 3 | 16 | Green Bay | S | Chris | Clemons | |
| 3 | 17 | New York N | HB | Glen | Coffee | |
| 3 | 18 | Buffalo | T | Will | Beatty | |
| ROUND 4 |
| 4 | 1 | Dallas | LB | K.C. | Asiodu | |
| 4 | 2 | Seattle | DE | David | Veikune | |
| 4 | 3 | Philadelphia | G | Andrew | Hartine | |
| 4 | 4 | Indianapolis | T | Ryan | McKee | |
| 4 | 5 | Washington | DT | Ogemdi | Nwagbuo | |
| 4 | 6 | Buffalo | G | Tyronne | Green | |
| 4 | 7 | Oakland | QB | Mike | Teel | |
| 4 | 8 | Pittsburgh | G | Jonathan | Compas | |
| 4 | 9 | New England | S | Macho | Harris | |
| 4 | 10 | San Francisco | DT | Roy | Miller | |
| 4 | 11 | New York A | CB | Jerraud | Powers | |
| 4 | 12 | San Diego | C | Doug | Legursky | |
| 4 | 13 | Cleveland | QB | Pat | White | |
| 4 | 14 | Buffalo | G | Herman | Johnson | |
| 4 | 15 | Denver | LB | Brian | Orakpa | |
| 4 | 16 | Green Bay | WR | Ramses | Barden | |
| 4 | 17 | New York N | DE | Kyle | Moore | |
| 4 | 18 | Buffalo | TE | Richard | Quinn | |
| ROUND 5 |
| 5 | 1 | Dallas | WR | Britt | Kenny | |
| 5 | 2 | Seattle | TE | Chase | Coffman | |
| 5 | 3 | Philadelphia | S | C.J. | Spillman | |
| 5 | 4 | Indianapolis | T | Demar | Dotson | |
| 5 | 5 | Washington | LB | Jason | Phillips | |
| 5 | 6 | New York N | DE | Nick | Reed | |
| 5 | 7 | Oakland | S | Lendy | Holmes | |
| 5 | 8 | Pittsburgh | T | Troy | Kropog | |
| 5 | 9 | New England | T | Xavier | Fulton | |
| 5 | 10 | San Francisco | S | Kevin | Ellison | |
| 5 | 11 | Detroit | HB | Chris | Presley | |
| 5 | 12 | San Diego | HB | Tyler | Roehl | |
| 5 | 13 | Cleveland | T | Phil | Trautwein | |
| 5 | 14 | Tampa Bay | TE | Shawn | Nelson | |
| 5 | 15 | Denver | CB | Don | Carey | |
| 5 | 16 | Green Bay | LB | Britt | Miller | |
| 5 | 17 | New York N | DT | Desmond | Bryant | |
| 5 | 18 | New York N | WR | Louis | Murphy | |
| ROUND 6 |
| 6 | 1 | Dallas | HB | Andre | Brown | |
| 6 | 2 | Seattle | S | Troy | Parson | |
| 6 | 3 | Detroit | C | Edwin | Williams | |
| 6 | 4 | Indianapolis | CB | Glover | Quin | |
| 6 | 5 | Washington | FB | Marcus | Mailei | |
| 6 | 6 | New York A | DT | Sen'Derrick | Marks | |
| 6 | 7 | Oakland | T | George | Bussey | |
| 6 | 8 | Pittsburgh | S | Stephen | Hodge | |
| 6 | 9 | New England | G | Darrly | Harris | |
| 6 | 10 | San Francisco | LB | Marcus | Freeman | |
| 6 | 11 | New York N | G | Roger | Allen | |
| 6 | 12 | San Diego | DT | Darell | Scott | |
| 6 | 13 | Cleveland | LB | Jamaal | Westerman | |
| 6 | 14 | Tampa Bay | FB | Frank | Summers | |
| 6 | 15 | Denver | S | Alan | Ball | |
| 6 | 16 | Green Bay | HB | Stefan | Logan | |
| 6 | 17 | New York N | HB | Cedric | Peerman | |
| 6 | 18 | Buffalo | G | Kyle | DeVan | |
| ROUND 7 |
| 7 | 1 | Dallas | LB | J.D. | Folsom | |
| 7 | 2 | Seattle | CB | Victor | Harris | |
| 7 | 3 | Detroit | LB | Larry | English | |
| 7 | 4 | Indianapolis | HB | Frank | Summers | |
| 7 | 5 | Washington | G | Brandyn | Dombrowski | |
| 7 | 6 | New York A | DT | Nick | Stonebreaker | |
| 7 | 7 | Oakland | WR | Deon | Butler | |
| 7 | 8 | Pittsburgh | DT | Vance | Walker | |
| 7 | 9 | San Francisco | C | Eric | Wood | |
| 7 | 10 | San Francisco | WR | Jarett | Dillard | |
| 7 | 11 | Seattle | K | Lawrence | Tynes | |
| 7 | 12 | San Diego | WR | Quinten | Lawrence | |
| 7 | 13 | Cleveland | WR | Nick | Miller | |
| 7 | 14 | Tampa Bay | T | Fenuki | Tupou | |
| 7 | 15 | Denver | WR | Mike | Thomas | |
| 7 | 16 | Green Bay | G | Kraig | Urbik | |
| 7 | 17 | New York N | K | David | Buehler | |
| 7 | 18 | Detroit | DT | Antonio | Dixon | |