| Round | Pick | Team | Position | First | Last | Player ID |
|---|
| ROUND 1 |
| 1 | 1 | Green Bay | DE | Chris | Long | |
| 1 | 2 | Washington | CB | Tracy | Porter | |
| 1 | 3 | Pittsburgh | HB | Darren | McFadden | |
| 1 | 4 | Tampa Bay | WR | James | Hardy | |
| 1 | 5 | Denver | T | Jake | Long | |
| 1 | 6 | New England | CB | Antoine | Cason | |
| 1 | 7 | Philadelphia | CB | Leotis | McKelvin | |
| 1 | 8 | Cleveland | DT | Glen | Dorsey | |
| 1 | 9 | Oakland | T | Ryan | Clady | |
| 1 | 10 | Carolina | HB | Jonathan | Stewart | |
| 1 | 11 | Washington | LB | Keith | Rivers | |
| 1 | 12 | New York N | LB | Curtis | Lofton | |
| 1 | 13 | Houston | CB | Dominique | Cromartie | |
| 1 | 14 | New York A | QB | Matt | Ryan | |
| 1 | 15 | Dallas | WR | Malcolm | Kelly | |
| 1 | 16 | Cleveland | G | Branden | Albert | |
| 1 | 17 | Washington | S | Tyrell | Johnson | |
| 1 | 18 | Philadelphia | LB | Jerod | Mayo | |
| ROUND 2 |
| 2 | 1 | Green Bay | C | Mike | Pollak | |
| 2 | 2 | Cleveland | DE | Derrick | Harvey | |
| 2 | 3 | Pittsburgh | S | Craig | Steltz | |
| 2 | 4 | Tampa Bay | LB | Beau | Bell | |
| 2 | 5 | Denver | LB | Dan | Connor | |
| 2 | 6 | New England | DT | Sedrick | Ellis | |
| 2 | 7 | Dallas | HB | Chris | Johnson | |
| 2 | 8 | Cleveland | FB | Jacob | Hester | |
| 2 | 9 | Oakland | DE | Vernon | Gholston | |
| 2 | 10 | Carolina | T | Gosder | Cherilus | |
| 2 | 11 | Buffalo | CB | Aqib | Talib | |
| 2 | 12 | New York N | HB | Kevin | Smith | |
| 2 | 13 | Houston | DT | Trevor | Laws | |
| 2 | 14 | New York A | WR | Eddie | Royal | |
| 2 | 15 | Dallas | S | Quintin | Demps | |
| 2 | 16 | San Francisco | CB | Brandon | Flowers | |
| 2 | 17 | Buffalo | WR | DeSean | Jackson | |
| 2 | 18 | San Francisco | DE | Phillip | Merling | |
| ROUND 3 |
| 3 | 1 | Green Bay | QB | Joe | Flacco | |
| 3 | 2 | Washington | WR | Devin | Thomas | |
| 3 | 3 | Pittsburgh | LB | Tavaris | Gooden | |
| 3 | 4 | Tampa Bay | HB | Felix | Jones | |
| 3 | 5 | Denver | S | Kenny | Phillips | |
| 3 | 6 | New England | S | DeJaun | Morgan | |
| 3 | 7 | Pittsburgh | LB | Shawn | Crable | |
| 3 | 8 | Cleveland | TE | Dustin | Keller | |
| 3 | 9 | Oakland | LB | Jordon | Dizon | |
| 3 | 10 | Carolina | G | Jeremy | Zuttah | |
| 3 | 11 | Buffalo | T | Duane | Brown | |
| 3 | 12 | New York N | G | Chilo | Rachal | |
| 3 | 13 | Houston | T | Chris | Williams | |
| 3 | 14 | Cleveland | WR | Jordy | Nelson | |
| 3 | 15 | Cleveland | LB | Bryan | Smith | |
| 3 | 16 | San Francisco | T | Sam | Baker | |
| 3 | 17 | Buffalo | WR | Dexter | Jackson | |
| 3 | 18 | Cleveland | S | Caleb | Campbell | |
| ROUND 4 |
| 4 | 1 | Green Bay | CB | Mike | Jenkin | |
| 4 | 2 | Detroit | C | Cody | Wallace | |
| 4 | 3 | Pittsburgh | T | Jeff | Otah | |
| 4 | 4 | Washington | T | Chad | Rinehart | |
| 4 | 5 | Denver | T | John | Greco | |
| 4 | 6 | New England | G | Josh | Sitton | |
| 4 | 7 | Philadelphia | T | Mike | McGlynn | |
| 4 | 8 | Cleveland | WR | Donnie | Avery | |
| 4 | 9 | Oakland | HB | Rashard | Mendenhall | |
| 4 | 10 | Carolina | LB | Cliff | Avril | |
| 4 | 11 | Buffalo | G | Roy | Schuening | |
| 4 | 12 | New York N | DT | Pat | Sims | |
| 4 | 13 | Houston | WR | Jerome | Simpson | |
| 4 | 14 | Buffalo | QB | Chad | Henne | |
| 4 | 15 | Denver | T | Tony | Hills | |
| 4 | 16 | San Francisco | S | Patrick | Lee | |
| 4 | 17 | Buffalo | G | Donald | Thomas | |
| 4 | 18 | Detroit | CB | Terrence | Wheatley | |
| ROUND 5 |
| 5 | 1 | Green Bay | S | Tom | Zbikowski | |
| 5 | 2 | Washington | G | Kory | Lichtensteig | |
| 5 | 3 | Baltimore | QB | Brian | Brohm | |
| 5 | 4 | Tampa Bay | FB | Jerome | Felton | |
| 5 | 5 | Denver | T | Shawn | Murphy | |
| 5 | 6 | New England | FB | Owen | Schmitt | |
| 5 | 7 | Philadelphia | WR | Limas | Sweed | |
| 5 | 8 | Cleveland | WR | Mario | Manningham | |
| 5 | 9 | Oakland | C | John | Sullivan | |
| 5 | 10 | Carolina | LB | Philip | Wheeler | |
| 5 | 11 | Baltimore | DT | Kentwan | Balmer | |
| 5 | 12 | New York N | QB | Matt | Flynn | |
| 5 | 13 | Houston | TE | Martellus | Bennett | |
| 5 | 14 | New York A | TE | John | Carlson | |
| 5 | 15 | Philadelphia | DT | Kendall | Langford | |
| 5 | 16 | San Francisco | CB | Charles | Godfrey | |
| 5 | 17 | Baltimore | WR | Early | Doucet | |
| 5 | 18 | Detroit | T | David | Hale | |
| ROUND 6 |
| 6 | 1 | Green Bay | T | Anthony | Collins | |
| 6 | 2 | Washington | DE | Lawrence | Jackson | |
| 6 | 3 | Pittsburgh | DE | Calais | Campbell | |
| 6 | 4 | Tampa Bay | HB | Ray | Rice | |
| 6 | 5 | Denver | HB | Jamaal | Charles | |
| 6 | 6 | New England | K | Dan | Carpenter | |
| 6 | 7 | Philadelphia | P | Sam | Paulescu | |
| 6 | 8 | Cleveland | TE | Fred | Davis | |
| 6 | 9 | Oakland | HB | Thomas | Brown | |
| 6 | 10 | Carolina | DE | Quentin | Groves | |
| 6 | 11 | Baltimore | G | Mackenzy | Bernadeau | |
| 6 | 12 | New York N | QB | Kevin | O'Connell | |
| 6 | 13 | Houston | QB | Dennis | Dixon | |
| 6 | 14 | New York A | C | Steve | Justice | |
| 6 | 15 | Denver | TE | Craig | Stevens | |
| 6 | 16 | San Francisco | P | Brett | Kern | |
| 6 | 17 | Baltimore | DE | Jason | Jones | |
| 6 | 18 | Detroit | LB | Bryan | Kehl | |
| ROUND 7 |
| 7 | 1 | Green Bay | DT | Andre | Fluellen | |
| 7 | 2 | Washington | DT | Dre | Moore | |
| 7 | 3 | Pittsburgh | HB | Matt | Forte | |
| 7 | 4 | Tampa Bay | WR | Earl | Bennett | |
| 7 | 5 | Denver | WR | Harry | Douglas | |
| 7 | 6 | New England | DT | DeMario | Pressley | |
| 7 | 7 | Philadelphia | QB | John David | Booty | |
| 7 | 8 | Cleveland | G | Chester | Adams | |
| 7 | 9 | Oakland | DE | Trevor | Scott | |
| 7 | 10 | Carolina | S | Thomas | DeCoud | |
| 7 | 11 | Baltimore | CB | Tyvon | Branch | |
| 7 | 12 | New York N | G | Brandon | Keith | |
| 7 | 13 | Houston | DE | Kenny | Iwebema | |
| 7 | 14 | New York A | WR | Andre | Caldwell | |
| 7 | 15 | Dallas | HB | Steve | Slaton | |
| 7 | 16 | Buffalo | QB | Erik | Ainge | |
| 7 | 17 | Baltimore | TE | Jermichael | Finley | |
| 7 | 18 | Detroit | TE | Brad | Cottam | |