| Round | Pick | Team | Position | First | Last | Player ID |
|---|
| ROUND 1 |
| 1 | 1 | New York A | WR | Calvin | Johnson | |
| 1 | 2 | New England | DE | Jamaal | Anderson | |
| 1 | 3 | Houston | HB | Adrian | Peterson | |
| 1 | 4 | Philadelphia | HB | Kenny | Irons | |
| 1 | 5 | Oakland | T | Levi | Brown | |
| 1 | 6 | Buffalo | S | Michael | Griffin | |
| 1 | 7 | New York N | LB | Lawrence | Timmons | |
| 1 | 8 | Tampa Bay | WR | Sidney | Rice | |
| 1 | 9 | Pittsburgh | CB | Darrelle | Revis | |
| 1 | 10 | Denver | CB | Aaron | Ross | |
| 1 | 11 | Dallas | CB | Eric | Wright | |
| 1 | 12 | Oakland | G | Ben | Grubbs | |
| 1 | 13 | Dallas | CB | Jonathan | Wade | |
| 1 | 14 | Green Bay | CB | John | Bowie | |
| 1 | 15 | Cleveland | LB | Paul | Posluszny | |
| 1 | 16 | San Francisco | DT | Amobi | Okoye | |
| 1 | 17 | Houston | T | Tony | Ugoh | |
| 1 | 18 | Carolina | DE | Jarvis | Moss | |
| ROUND 2 |
| 2 | 1 | New York A | LB | Justin | Durant | |
| 2 | 2 | New England | CB | Usama | Young | |
| 2 | 3 | Houston | T | Mario | Henderson | |
| 2 | 4 | Oakland | C | Ryan | Kalil | |
| 2 | 5 | Buffalo | DE | LaMarr | Woodley | |
| 2 | 6 | New York N | HB | Brandon | Jackson | |
| 2 | 7 | Tampa Bay | QB | JaMarcus | Russell | |
| 2 | 8 | Pittsburgh | LB | Buster | Davis | |
| 2 | 9 | Houston | G | Arron | Sears | |
| 2 | 10 | Oakland | T | Doug | Free | |
| 2 | 11 | Oakland | G | Manuel | Ramirez | |
| 2 | 12 | San Francisco | TE | Zach | Miller | |
| 2 | 13 | Green Bay | LB | Michael | Okwo | |
| 2 | 14 | Cleveland | CB | AJ | Davis | |
| 2 | 15 | San Francisco | S | Dashon | Goldson | |
| 2 | 16 | New York N | DT | Alan | Branch | |
| 2 | 17 | Washington | LB | Zak | Deossie | |
| 2 | 18 | Carolina | CB | Brandon | McDonald | |
| ROUND 3 |
| 3 | 1 | New York A | S | Brandon | Meriweather | |
| 3 | 2 | New England | LB | Clint | Sessions | |
| 3 | 3 | Dallas | WR | Yamon | Figurs | |
| 3 | 4 | Philadelphia | WR | Dwayne | Bowe | |
| 3 | 5 | Buffalo | TE | Greg | Olsen | |
| 3 | 6 | New York N | DT | Brandon | Mebane | |
| 3 | 7 | Tampa Bay | TE | Matt | Spaeth | |
| 3 | 8 | Pittsburgh | S | Gerald | Alexander | |
| 3 | 9 | Denver | WR | Craig | Davis | |
| 3 | 10 | Pittsburgh | QB | Brady | Quinn | |
| 3 | 11 | San Francisco | WR | Jason | Hill | |
| 3 | 12 | Green Bay | WR | Chris | Davis | |
| 3 | 13 | Cleveland | DT | Jay | Alford | |
| 3 | 14 | San Francisco | CB | Corey | Graham | |
| 3 | 15 | Dallas | T | Ryan | Harris | |
| 3 | 16 | Washington | WR | Steve | Smith | |
| 3 | 17 | Carolina | DE | Victor | Abiamiri | |
| 3 | 18 | Washington | S | Aaron | Rouse | |
| ROUND 4 |
| 4 | 1 | New York A | FB | Brian | Leonard | |
| 4 | 2 | New England | DT | Kareem | Brown | |
| 4 | 3 | Philadelphia | QB | Kevin | Kolb | |
| 4 | 4 | Philadelphia | WR | Johnnie Lee | Higgins | |
| 4 | 5 | Buffalo | HB | Tony | Hunt | |
| 4 | 6 | New York N | WR | Mike | Walker | |
| 4 | 7 | Tampa Bay | DE | Dan | Bazuin | |
| 4 | 8 | Dallas | C | Samson | Satele | |
| 4 | 9 | Houston | G | Andy | Alleman | |
| 4 | 10 | Philadelphia | CB | Tarell | Brown | |
| 4 | 11 | Oakland | LB | Johnny | Baldwin | |
| 4 | 12 | Philadelphia | S | Brandon | Harrison | |
| 4 | 13 | Green Bay | LB | Tim | Shaw | |
| 4 | 14 | Cleveland | LB | Stephen | Nicholas | |
| 4 | 15 | San Francisco | WR | Aundrae | Allison | |
| 4 | 16 | Baltimore | G | Mansfield | Wrotto | |
| 4 | 17 | Carolina | LB | HB | Blades | |
| 4 | 18 | Carolina | WR | Joel | Filani | |
| ROUND 5 |
| 5 | 1 | New York A | QB | John | Beck | |
| 5 | 2 | New England | S | Michael | Johnson | |
| 5 | 3 | Houston | FB | Le'Ron | McClain | |
| 5 | 4 | Dallas | T | Aaron | Brant | |
| 5 | 5 | Buffalo | WR | John | Broussard | |
| 5 | 6 | New York N | DE | Charles | Johnson | |
| 5 | 7 | Tampa Bay | DT | Paul | Soliai | |
| 5 | 8 | Detroit | T | Mike | Rolfe | |
| 5 | 9 | Denver | S | Eric | Frampton | |
| 5 | 10 | Pittsburgh | G | Josh | Beekman | |
| 5 | 11 | Dallas | DE | Baraka | Atkins | |
| 5 | 12 | Houston | C | Leroy | Harris | |
| 5 | 13 | Green Bay | G | Justin | Blalock | |
| 5 | 14 | Cleveland | WR | Roy | Hall | |
| 5 | 15 | San Francisco | TE | Scott | Chandler | |
| 5 | 16 | Baltimore | T | Brandon | Frye | |
| 5 | 17 | Washington | LB | Desmond | Bishop | |
| 5 | 18 | Carolina | CB | Rashad | Barksdale | |
| ROUND 6 |
| 6 | 1 | New England | T | Jacob | Bender | |
| 6 | 2 | Houston | HB | Michael | Bush | |
| 6 | 3 | Dallas | QB | Drew | Stanton | |
| 6 | 4 | Buffalo | S | John | Wendling | |
| 6 | 5 | New York N | CB | Michael | Coe | |
| 6 | 6 | Tampa Bay | FB | Orenthal | O'Neal | |
| 6 | 7 | Pittsburgh | P | Adam | Podlesh | |
| 6 | 8 | Denver | P | Daniel | Sepulveda | |
| 6 | 9 | Dallas | T | Kendrick | Shackleford | |
| 6 | 10 | Oakland | WR | Jordan | Kent | |
| 6 | 11 | Dallas | G | Dan | Santucci | |
| 6 | 12 | Green Bay | K | Tim | Fralic | |
| 6 | 13 | Cleveland | K | Blaise | Holland | |
| 6 | 14 | San Francisco | LB | Sebastian | Bolden | |
| 6 | 15 | Houston | DT | Greg | Peterson | |
| 6 | 16 | Washington | WR | Derek | Stanley | |
| 6 | 17 | Carolina | T | Corey | Hilliard | |
| 6 | 18 | New England | G | Kasey | Studdard | |
| ROUND 7 |
| 7 | 1 | Houston | DE | Keith | Ashley | |
| 7 | 2 | Dallas | T | Mike | Otto | |
| 7 | 3 | Buffalo | CB | Ryan | Smith | |
| 7 | 4 | New York N | S | Nedu | Ndukwe | |
| 7 | 5 | Tampa Bay | K | Darrell | Lucas | |
| 7 | 6 | Pittsburgh | FB | Reagan | Mauia | |
| 7 | 7 | Denver | FB | Deon | Anderson | |
| 7 | 8 | Baltimore | HB | Thomas | Clayton | |
| 7 | 9 | Oakland | TE | Kevin | Boss | |
| 7 | 10 | Dallas | QB | Jeff | Rowe | |
| 7 | 11 | Green Bay | DE | Brian | Robison | |
| 7 | 12 | Cleveland | P | Sawyer | Anderson | |
| 7 | 13 | Pittsburgh | TE | Dante | Rosario | |
| 7 | 14 | Houston | DT | Ralph | Dishman | |
| 7 | 15 | Washington | LB | Adam | Hayward | |