| Round | Pick | Team | Position | First | Last | Player ID |
|---|
| ROUND 1 |
| 1 | 1 | New York | HB | Laurence | Maroney | |
| 1 | 2 | San Diego | QB | Jay | Cutler | |
| 1 | 3 | Dallas | S | Danieal | Manning | |
| 1 | 4 | Cleveland | G | Taitusi | Lutui | |
| 1 | 5 | Philadelphia | G | Max | Jean-Gilles | |
| 1 | 6 | Pittsburgh | HB | Joseph | Addai | |
| 1 | 7 | Washington | QB | Vince | Young | |
| 1 | 8 | Oakland | QB | Tarvaris | Jackson | |
| 1 | 9 | San Francisco | QB | Brodie | Croyle | |
| 1 | 10 | Buffalo | LB | Ernie | Sims | |
| 1 | 11 | Atlanta | CB | Antonio | Cromartie | |
| 1 | 12 | Philadelphia | CB | Tye | Hill | |
| 1 | 13 | San Diego | WR | Santonio | Holmes | |
| 1 | 14 | Baltimore | CB | Kelly | Jennings | |
| 1 | 15 | Philadelphia | HB | Maurice | Drew | |
| 1 | 16 | Green Bay | T | D'Brickasha | Ferguson | |
| 1 | 17 | New England | WR | Maurice | Stovall | |
| 1 | 18 | Tampa Bay | CB | Cedric | Griffin | |
| ROUND 2 |
| 2 | 1 | New York | G | Rob | Sims | |
| 2 | 2 | Detroit | DE | Mathias | Kiwanuka | |
| 2 | 3 | Dallas | DT | Haloti | Ngata | |
| 2 | 4 | Cleveland | CB | Tim | Jennings | |
| 2 | 5 | Dallas | TE | Mercedes | Lewis | |
| 2 | 6 | Seattle | DE | Kamerion | Wimbley | |
| 2 | 7 | Detroit | WR | Devin | Hester | |
| 2 | 8 | Oakland | DT | John | McCargo | |
| 2 | 9 | San Francisco | DE | Jason | Hatcher | |
| 2 | 10 | Buffalo | LB | Bobby | Carpenter | |
| 2 | 11 | Atlanta | DE | Chris | Gocong | |
| 2 | 12 | Dallas | LB | DeMeco | Ryans | |
| 2 | 13 | Seattle | S | Donte | Whitner | |
| 2 | 14 | Baltimore | LB | Roger | McIntosh | |
| 2 | 15 | Detroit | S | Bernard | Pollard | |
| 2 | 16 | Green Bay | WR | Greg | Jennings | |
| 2 | 17 | Denver | HB | Jerious | Norwood | |
| 2 | 18 | Detroit | WR | Sinorice | Moss | |
| ROUND 3 |
| 3 | 1 | New York | LB | Abdul | Hodge | |
| 3 | 2 | Washington | CB | DeMario | Minter | |
| 3 | 3 | New England | S | Vickiel | Vaughn | |
| 3 | 4 | Cleveland | S | Eric | Smith | |
| 3 | 5 | Tampa Bay | T | Daryn | Colledge | |
| 3 | 6 | Pittsburgh | WR | Brandon | Williams | |
| 3 | 7 | San Diego | DT | Dusty | Dvoracek | |
| 3 | 8 | Oakland | T | Andrew | Whitworth | |
| 3 | 9 | San Francisco | WR | Derek | Hagan | |
| 3 | 10 | Buffalo | C | Ryan | Cook | |
| 3 | 11 | Atlanta | CB | David | Pittman | |
| 3 | 12 | Philadelphia | K | Rich | Lane | |
| 3 | 13 | Philadelphia | LB | Jon | Alston | |
| 3 | 14 | Baltimore | TE | Joe | Klopfenstein | |
| 3 | 15 | Philadelphia | S | Calvin | Lowry | |
| 3 | 16 | Green Bay | T | Charles | Spencer | |
| 3 | 17 | Denver | TE | Anthony | Fasano | |
| 3 | 18 | Philadelphia | LB | James | Anderson | |
| ROUND 4 |
| 4 | 1 | New York | QB | Omar | Jacobs | |
| 4 | 2 | San Diego | C | Jason | Spitz | |
| 4 | 3 | New England | C | Dave | McMahon | |
| 4 | 4 | Cleveland | FB | Warren | Covington | |
| 4 | 5 | Dallas | G | Ryan | O'Callaghan | |
| 4 | 6 | San Diego | LB | Dale | Robinson | |
| 4 | 7 | San Diego | WR | Michael | Robinson | |
| 4 | 8 | Oakland | FB | Mike | Pickett | |
| 4 | 9 | San Francisco | T | Dick | Carlson | |
| 4 | 10 | Buffalo | HB | P.J. | Daniels | |
| 4 | 11 | Atlanta | T | Myron | Carlson | |
| 4 | 12 | Seattle | TE | Leonard | Pope | |
| 4 | 13 | New England | TE | Dominique | Byrd | |
| 4 | 14 | Baltimore | DT | Domata | Peko | |
| 4 | 15 | Pittsburgh | CB | Josh | Lay | |
| 4 | 16 | Green Bay | WR | Brad | Smith | |
| 4 | 17 | Denver | K | Eric | Brown | |
| 4 | 18 | Tampa Bay | G | Tyler | Reed | |
| ROUND 5 |
| 5 | 1 | New York | DT | Orien | Harris | |
| 5 | 2 | Baltimore | DE | Rob | Ninkovich | |
| 5 | 3 | Dallas | CB | Anwar | Phillips | |
| 5 | 4 | Cleveland | S | Nate | Salley | |
| 5 | 5 | Tampa Bay | CB | Drew | Coleman | |
| 5 | 6 | Pittsburgh | LB | Stephen | Tulloch | |
| 5 | 7 | Washington | K | Donovan | Tiggle | |
| 5 | 8 | Oakland | LB | Gerris | Wilkinson | |
| 5 | 9 | San Francisco | WR | Cory | Rodgers | |
| 5 | 10 | Buffalo | WR | Will | Blackmon | |
| 5 | 11 | Atlanta | DT | Kader | Drame | |
| 5 | 12 | San Diego | LB | Terna | Nande | |
| 5 | 13 | San Diego | WR | Demetrius | Williams | |
| 5 | 14 | Baltimore | S | Dawan | Landry | |
| 5 | 15 | San Diego | S | Charlie | Peprah | |
| 5 | 16 | Green Bay | T | Rashad | Butler | |
| 5 | 17 | Denver | DE | Elvis | Dumervil | |
| 5 | 18 | Dallas | DE | Mike | Kudla | |
| ROUND 6 |
| 6 | 1 | New York | S | Tyrone | Culver | |
| 6 | 2 | San Diego | P | Rodney | Brock | |
| 6 | 3 | Philadelphia | CB | Andre | Lewis | |
| 6 | 4 | Cleveland | T | Joe | Toledo | |
| 6 | 5 | Tampa Bay | TE | Jeff | King | |
| 6 | 6 | Pittsburgh | DT | Anthony | Montgomery | |
| 6 | 7 | Dallas | T | Quinn | Ojinnaka | |
| 6 | 8 | Oakland | TE | Dave | Thomas | |
| 6 | 9 | San Francisco | FB | Anthony | Washington | |
| 6 | 10 | Buffalo | WR | Brandon | Marshall | |
| 6 | 11 | Atlanta | FB | Oscar | Green | |
| 6 | 12 | New England | CB | Tim | Johnston | |
| 6 | 13 | Dallas | HB | Wali | Lundy | |
| 6 | 14 | Baltimore | HB | Quinton | Ganther | |
| 6 | 15 | Dallas | G | Willie | Toliver | |
| 6 | 16 | Green Bay | P | Ira | Rogers | |
| 6 | 17 | Denver | T | Ervin | Miller | |
| 6 | 18 | Dallas | DE | Julian | Jenkins | |
| ROUND 7 |
| 7 | 1 | New York | T | Brad | Butler | |
| 7 | 2 | San Diego | DT | LeKevin | Smith | |
| 7 | 3 | Philadelphia | LB | Tim | Dobbins | |
| 7 | 4 | Cleveland | DE | Brent | Hawkins | |
| 7 | 5 | Tampa Bay | S | Justin | Hamilton | |
| 7 | 6 | Pittsburgh | CB | Justin | Phinisee | |
| 7 | 7 | Washington | WR | Domenik | Hixon | |
| 7 | 8 | Dallas | T | Al | Kelly | |
| 7 | 9 | San Francisco | G | Michael | Toudouze | |
| 7 | 10 | Buffalo | TE | Garrett | Mills | |
| 7 | 11 | Atlanta | C | Chris | Morris | |
| 7 | 12 | New England | DE | Vinny | Smith | |
| 7 | 13 | San Diego | FB | John | Bickett | |
| 7 | 14 | Baltimore | HB | Andre | Hall | |
| 7 | 15 | San Diego | LB | Omar | Gaither | |
| 7 | 16 | Green Bay | LB | Charles | Bennett | |
| 7 | 17 | Denver | S | Antoine | Bethea | |
| 7 | 18 | Dallas | WR | Greg | Lee | |